A highly differentiated region of wheat chromosome 7AL encodes a Pm1a immune receptor that recognises its corresponding AvrPm1a effector from Blumeria graminis.
Identifieur interne : 000233 ( Main/Exploration ); précédent : 000232; suivant : 000234A highly differentiated region of wheat chromosome 7AL encodes a Pm1a immune receptor that recognises its corresponding AvrPm1a effector from Blumeria graminis.
Auteurs : Tim Hewitt [Australie] ; Marion C. Mueller [Suisse] ; István Molnár [République tchèque] ; Martin Mascher [Allemagne] ; Kate Ina Holušová [République tchèque] ; Hana Šimková [République tchèque] ; Lukas Kunz [Suisse] ; Jianping Zhang [Australie] ; Jianbo Li [Australie] ; Dhara Bhatt [Australie] ; Raghvendra Sharma [Australie] ; Seraina Schudel [Suisse] ; Guotai Yu [Royaume-Uni] ; Burkhard Steuernagel [Royaume-Uni] ; Sambasivam Periyannan [Australie] ; Brande Wulff [Royaume-Uni] ; Mick Ayliffe [Australie] ; Robert Mcintosh [Australie] ; Beat Keller [Suisse] ; Evans Lagudah [Australie] ; Peng Zhang [Australie]Source :
- The New phytologist [ 1469-8137 ] ; 2020.
Abstract
Pm1a, the first powdery mildew resistance gene described in wheat, is part of a complex resistance (R) gene cluster located in a distal region of chromosome 7AL that has suppressed genetic recombination. A nucleotide-binding, leucine-rich repeat (NLR) immune receptor gene was isolated using mutagenesis and R gene enrichment sequencing (MutRenSeq). Stable transformation confirmed Pm1a identity which induced a strong resistance phenotype in transgenic plants upon challenge with avirulent Blumeria graminis (wheat powdery mildew) pathogens. A high-density genetic map of a B. graminis family segregating for Pm1a avirulence combined with pathogen genome resequencing and RNAseq identified AvrPm1a effector gene candidates. In planta expression identified an effector, with an N terminal Y/FxC motif, that induced a strong hypersensitive response when co-expressed with Pm1a in Nicotiana benthamiana. Single chromosome enrichment sequencing (ChromSeq) and assembly of chromosome 7A suggested that suppressed recombination around the Pm1a region was due to a rearrangement involving chromosomes 7A, 7B and 7D. The cloning of Pm1a and its identification in a highly rearranged region of chromosome 7A provides insight into the role of chromosomal rearrangements in the evolution of this complex resistance cluster.
DOI: 10.1111/nph.17075
PubMed: 33176001
Affiliations:
- Allemagne, Australie, Royaume-Uni, République tchèque, Suisse
- Canton de Zurich, Nouvelle-Galles du Sud
- Sydney, Zurich
- Université de Sydney, Université de Zurich
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7UH</wicri:regionArea><wicri:noRegion>NR4 7UH</wicri:noRegion></affiliation></author><author><name sortKey="Periyannan, Sambasivam" sort="Periyannan, Sambasivam" uniqKey="Periyannan S" first="Sambasivam" last="Periyannan">Sambasivam Periyannan</name><affiliation wicri:level="1"><nlm:affiliation>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601</wicri:regionArea><wicri:noRegion>2601</wicri:noRegion></affiliation></author><author><name sortKey="Wulff, Brande" sort="Wulff, Brande" uniqKey="Wulff B" first="Brande" last="Wulff">Brande Wulff</name><affiliation wicri:level="1"><nlm:affiliation>John Innes Centre, Norwich, NR4 7UH, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>John Innes Centre, Norwich, NR4 7UH</wicri:regionArea><wicri:noRegion>NR4 7UH</wicri:noRegion></affiliation></author><author><name sortKey="Ayliffe, Mick" sort="Ayliffe, Mick" uniqKey="Ayliffe M" first="Mick" last="Ayliffe">Mick Ayliffe</name><affiliation wicri:level="1"><nlm:affiliation>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601</wicri:regionArea><wicri:noRegion>2601</wicri:noRegion></affiliation></author><author><name sortKey="Mcintosh, Robert" sort="Mcintosh, Robert" uniqKey="Mcintosh R" first="Robert" last="Mcintosh">Robert Mcintosh</name><affiliation wicri:level="4"><nlm:affiliation>University of Sydney, School of Life and Environmental Sciences, Plant Breeding Institute, 107 Cobbitty Road, Cobbitty, NSW, 2570, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Sydney, School of Life and Environmental Sciences, Plant Breeding Institute, 107 Cobbitty Road, Cobbitty, NSW, 2570</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Keller, Beat" sort="Keller, Beat" uniqKey="Keller B" first="Beat" last="Keller">Beat Keller</name><affiliation wicri:level="4"><nlm:affiliation>University of Zurich, Department of Plant and Microbial Biology, Zollikerstrasse 107, 8008, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Zurich, Department of Plant and Microbial Biology, Zollikerstrasse 107, 8008, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName><orgName type="university">Université de Zurich</orgName></affiliation></author><author><name sortKey="Lagudah, Evans" sort="Lagudah, Evans" uniqKey="Lagudah E" first="Evans" last="Lagudah">Evans Lagudah</name><affiliation wicri:level="1"><nlm:affiliation>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601</wicri:regionArea><wicri:noRegion>2601</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>University of Sydney, School of Life and Environmental Sciences, Plant Breeding Institute, 107 Cobbitty Road, Cobbitty, NSW, 2570, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Sydney, School of Life and Environmental Sciences, Plant Breeding Institute, 107 Cobbitty Road, Cobbitty, NSW, 2570</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Zhang, Peng" sort="Zhang, Peng" uniqKey="Zhang P" first="Peng" last="Zhang">Peng Zhang</name><affiliation wicri:level="4"><nlm:affiliation>University of Sydney, School of Life and Environmental Sciences, Plant Breeding Institute, 107 Cobbitty Road, Cobbitty, NSW, 2570, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Sydney, School of Life and Environmental Sciences, Plant Breeding Institute, 107 Cobbitty Road, Cobbitty, NSW, 2570</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:33176001</idno><idno type="pmid">33176001</idno><idno type="doi">10.1111/nph.17075</idno><idno type="wicri:Area/Main/Corpus">000013</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000013</idno><idno type="wicri:Area/Main/Curation">000013</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000013</idno><idno type="wicri:Area/Main/Exploration">000013</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A highly differentiated region of wheat chromosome 7AL encodes a Pm1a immune receptor that recognises its corresponding AvrPm1a effector from Blumeria graminis.</title><author><name sortKey="Hewitt, Tim" sort="Hewitt, Tim" uniqKey="Hewitt T" first="Tim" last="Hewitt">Tim Hewitt</name><affiliation wicri:level="1"><nlm:affiliation>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601</wicri:regionArea><wicri:noRegion>2601</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>University of Sydney, School of Life and Environmental Sciences, Plant Breeding Institute, 107 Cobbitty Road, Cobbitty, NSW, 2570, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Sydney, School of Life and Environmental Sciences, Plant Breeding Institute, 107 Cobbitty Road, Cobbitty, NSW, 2570</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Mueller, Marion C" sort="Mueller, Marion C" uniqKey="Mueller M" first="Marion C" last="Mueller">Marion C. Mueller</name><affiliation wicri:level="4"><nlm:affiliation>University of Zurich, Department of Plant and Microbial Biology, Zollikerstrasse 107, 8008, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Zurich, Department of Plant and Microbial Biology, Zollikerstrasse 107, 8008, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName><orgName type="university">Université de Zurich</orgName></affiliation></author><author><name sortKey="Molnar, Istvan" sort="Molnar, Istvan" uniqKey="Molnar I" first="István" last="Molnár">István Molnár</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Experimental Botany, Czech Academy of Sciences, Centre of the Region Haná for Biotechnological and Agricultural Research, Šlechtitelů 31, 779 00, Olomouc, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Institute of Experimental Botany, Czech Academy of Sciences, Centre of the Region Haná for Biotechnological and Agricultural Research, Šlechtitelů 31, 779 00, Olomouc</wicri:regionArea><wicri:noRegion>Olomouc</wicri:noRegion></affiliation></author><author><name sortKey="Mascher, Martin" sort="Mascher, Martin" uniqKey="Mascher M" first="Martin" last="Mascher">Martin Mascher</name><affiliation wicri:level="1"><nlm:affiliation>Leibniz Institute of Plant Genetics and Crop Plant Research, OT Gatersleben, Corrensstr. 3, D-06466, Stadt Seeland, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Leibniz Institute of Plant Genetics and Crop Plant Research, OT Gatersleben, Corrensstr. 3, D-06466, Stadt Seeland</wicri:regionArea><wicri:noRegion>06466, Stadt Seeland</wicri:noRegion><wicri:noRegion>06466, Stadt Seeland</wicri:noRegion><wicri:noRegion>Stadt Seeland</wicri:noRegion></affiliation></author><author><name sortKey="Holusova, Kate Ina" sort="Holusova, Kate Ina" uniqKey="Holusova K" first="Kate Ina" last="Holušová">Kate Ina Holušová</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Experimental Botany, Czech Academy of Sciences, Centre of the Region Haná for Biotechnological and Agricultural Research, Šlechtitelů 31, 779 00, Olomouc, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Institute of Experimental Botany, Czech Academy of Sciences, Centre of the Region Haná for Biotechnological and Agricultural Research, Šlechtitelů 31, 779 00, Olomouc</wicri:regionArea><wicri:noRegion>Olomouc</wicri:noRegion></affiliation></author><author><name sortKey="Simkova, Hana" sort="Simkova, Hana" uniqKey="Simkova H" first="Hana" last="Šimková">Hana Šimková</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Experimental Botany, Czech Academy of Sciences, Centre of the Region Haná for Biotechnological and Agricultural Research, Šlechtitelů 31, 779 00, Olomouc, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Institute of Experimental Botany, Czech Academy of Sciences, Centre of the Region Haná for Biotechnological and Agricultural Research, Šlechtitelů 31, 779 00, Olomouc</wicri:regionArea><wicri:noRegion>Olomouc</wicri:noRegion></affiliation></author><author><name sortKey="Kunz, Lukas" sort="Kunz, Lukas" uniqKey="Kunz L" first="Lukas" last="Kunz">Lukas Kunz</name><affiliation wicri:level="4"><nlm:affiliation>University of Zurich, Department of Plant and Microbial Biology, Zollikerstrasse 107, 8008, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Zurich, Department of Plant and Microbial Biology, Zollikerstrasse 107, 8008, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName><orgName type="university">Université de Zurich</orgName></affiliation></author><author><name sortKey="Zhang, Jianping" sort="Zhang, Jianping" uniqKey="Zhang J" first="Jianping" last="Zhang">Jianping Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601</wicri:regionArea><wicri:noRegion>2601</wicri:noRegion></affiliation></author><author><name sortKey="Li, Jianbo" sort="Li, Jianbo" uniqKey="Li J" first="Jianbo" last="Li">Jianbo Li</name><affiliation wicri:level="4"><nlm:affiliation>University of Sydney, School of Life and Environmental Sciences, Plant Breeding Institute, 107 Cobbitty Road, Cobbitty, NSW, 2570, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Sydney, School of Life and Environmental Sciences, Plant Breeding Institute, 107 Cobbitty Road, Cobbitty, NSW, 2570</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Bhatt, Dhara" sort="Bhatt, Dhara" uniqKey="Bhatt D" first="Dhara" last="Bhatt">Dhara Bhatt</name><affiliation wicri:level="1"><nlm:affiliation>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601</wicri:regionArea><wicri:noRegion>2601</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Raghvendra" sort="Sharma, Raghvendra" uniqKey="Sharma R" first="Raghvendra" last="Sharma">Raghvendra Sharma</name><affiliation wicri:level="1"><nlm:affiliation>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601</wicri:regionArea><wicri:noRegion>2601</wicri:noRegion></affiliation></author><author><name sortKey="Schudel, Seraina" sort="Schudel, Seraina" uniqKey="Schudel S" first="Seraina" last="Schudel">Seraina Schudel</name><affiliation wicri:level="4"><nlm:affiliation>University of Zurich, Department of Plant and Microbial Biology, Zollikerstrasse 107, 8008, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Zurich, Department of Plant and Microbial Biology, Zollikerstrasse 107, 8008, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName><orgName type="university">Université de Zurich</orgName></affiliation></author><author><name sortKey="Yu, Guotai" sort="Yu, Guotai" uniqKey="Yu G" first="Guotai" last="Yu">Guotai Yu</name><affiliation wicri:level="1"><nlm:affiliation>John Innes Centre, Norwich, NR4 7UH, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>John Innes Centre, Norwich, NR4 7UH</wicri:regionArea><wicri:noRegion>NR4 7UH</wicri:noRegion></affiliation></author><author><name sortKey="Steuernagel, Burkhard" sort="Steuernagel, Burkhard" uniqKey="Steuernagel B" first="Burkhard" last="Steuernagel">Burkhard Steuernagel</name><affiliation wicri:level="1"><nlm:affiliation>John Innes Centre, Norwich, NR4 7UH, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>John Innes Centre, Norwich, NR4 7UH</wicri:regionArea><wicri:noRegion>NR4 7UH</wicri:noRegion></affiliation></author><author><name sortKey="Periyannan, Sambasivam" sort="Periyannan, Sambasivam" uniqKey="Periyannan S" first="Sambasivam" last="Periyannan">Sambasivam Periyannan</name><affiliation wicri:level="1"><nlm:affiliation>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601</wicri:regionArea><wicri:noRegion>2601</wicri:noRegion></affiliation></author><author><name sortKey="Wulff, Brande" sort="Wulff, Brande" uniqKey="Wulff B" first="Brande" last="Wulff">Brande Wulff</name><affiliation wicri:level="1"><nlm:affiliation>John Innes Centre, Norwich, NR4 7UH, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>John Innes Centre, Norwich, NR4 7UH</wicri:regionArea><wicri:noRegion>NR4 7UH</wicri:noRegion></affiliation></author><author><name sortKey="Ayliffe, Mick" sort="Ayliffe, Mick" uniqKey="Ayliffe M" first="Mick" last="Ayliffe">Mick Ayliffe</name><affiliation wicri:level="1"><nlm:affiliation>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601</wicri:regionArea><wicri:noRegion>2601</wicri:noRegion></affiliation></author><author><name sortKey="Mcintosh, Robert" sort="Mcintosh, Robert" uniqKey="Mcintosh R" first="Robert" last="Mcintosh">Robert Mcintosh</name><affiliation wicri:level="4"><nlm:affiliation>University of Sydney, School of Life and Environmental Sciences, Plant Breeding Institute, 107 Cobbitty Road, Cobbitty, NSW, 2570, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Sydney, School of Life and Environmental Sciences, Plant Breeding Institute, 107 Cobbitty Road, Cobbitty, NSW, 2570</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Keller, Beat" sort="Keller, Beat" uniqKey="Keller B" first="Beat" last="Keller">Beat Keller</name><affiliation wicri:level="4"><nlm:affiliation>University of Zurich, Department of Plant and Microbial Biology, Zollikerstrasse 107, 8008, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>University of Zurich, Department of Plant and Microbial Biology, Zollikerstrasse 107, 8008, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName><orgName type="university">Université de Zurich</orgName></affiliation></author><author><name sortKey="Lagudah, Evans" sort="Lagudah, Evans" uniqKey="Lagudah E" first="Evans" last="Lagudah">Evans Lagudah</name><affiliation wicri:level="1"><nlm:affiliation>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601</wicri:regionArea><wicri:noRegion>2601</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:affiliation>University of Sydney, School of Life and Environmental Sciences, Plant Breeding Institute, 107 Cobbitty Road, Cobbitty, NSW, 2570, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Sydney, School of Life and Environmental Sciences, Plant Breeding Institute, 107 Cobbitty Road, Cobbitty, NSW, 2570</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Zhang, Peng" sort="Zhang, Peng" uniqKey="Zhang P" first="Peng" last="Zhang">Peng Zhang</name><affiliation wicri:level="4"><nlm:affiliation>University of Sydney, School of Life and Environmental Sciences, Plant Breeding Institute, 107 Cobbitty Road, Cobbitty, NSW, 2570, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Sydney, School of Life and Environmental Sciences, Plant Breeding Institute, 107 Cobbitty Road, Cobbitty, NSW, 2570</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author></analytic><series><title level="j">The New phytologist</title><idno type="eISSN">1469-8137</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pm1a, the first powdery mildew resistance gene described in wheat, is part of a complex resistance (R) gene cluster located in a distal region of chromosome 7AL that has suppressed genetic recombination. A nucleotide-binding, leucine-rich repeat (NLR) immune receptor gene was isolated using mutagenesis and R gene enrichment sequencing (MutRenSeq). Stable transformation confirmed Pm1a identity which induced a strong resistance phenotype in transgenic plants upon challenge with avirulent Blumeria graminis (wheat powdery mildew) pathogens. A high-density genetic map of a B. graminis family segregating for Pm1a avirulence combined with pathogen genome resequencing and RNAseq identified AvrPm1a effector gene candidates. In planta expression identified an effector, with an N terminal Y/FxC motif, that induced a strong hypersensitive response when co-expressed with Pm1a in Nicotiana benthamiana. Single chromosome enrichment sequencing (ChromSeq) and assembly of chromosome 7A suggested that suppressed recombination around the Pm1a region was due to a rearrangement involving chromosomes 7A, 7B and 7D. The cloning of Pm1a and its identification in a highly rearranged region of chromosome 7A provides insight into the role of chromosomal rearrangements in the evolution of this complex resistance cluster.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33176001</PMID><DateRevised><Year>2020</Year><Month>11</Month><Day>11</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1469-8137</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Nov</Month><Day>11</Day></PubDate></JournalIssue><Title>The New phytologist</Title><ISOAbbreviation>New Phytol</ISOAbbreviation></Journal><ArticleTitle>A highly differentiated region of wheat chromosome 7AL encodes a Pm1a immune receptor that recognises its corresponding AvrPm1a effector from Blumeria graminis.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1111/nph.17075</ELocationID><Abstract><AbstractText>Pm1a, the first powdery mildew resistance gene described in wheat, is part of a complex resistance (R) gene cluster located in a distal region of chromosome 7AL that has suppressed genetic recombination. A nucleotide-binding, leucine-rich repeat (NLR) immune receptor gene was isolated using mutagenesis and R gene enrichment sequencing (MutRenSeq). Stable transformation confirmed Pm1a identity which induced a strong resistance phenotype in transgenic plants upon challenge with avirulent Blumeria graminis (wheat powdery mildew) pathogens. A high-density genetic map of a B. graminis family segregating for Pm1a avirulence combined with pathogen genome resequencing and RNAseq identified AvrPm1a effector gene candidates. In planta expression identified an effector, with an N terminal Y/FxC motif, that induced a strong hypersensitive response when co-expressed with Pm1a in Nicotiana benthamiana. Single chromosome enrichment sequencing (ChromSeq) and assembly of chromosome 7A suggested that suppressed recombination around the Pm1a region was due to a rearrangement involving chromosomes 7A, 7B and 7D. The cloning of Pm1a and its identification in a highly rearranged region of chromosome 7A provides insight into the role of chromosomal rearrangements in the evolution of this complex resistance cluster.</AbstractText><CopyrightInformation>This article is protected by copyright. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hewitt</LastName><ForeName>Tim</ForeName><Initials>T</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-4888-7216</Identifier><AffiliationInfo><Affiliation>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Sydney, School of Life and Environmental Sciences, Plant Breeding Institute, 107 Cobbitty Road, Cobbitty, NSW, 2570, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mueller</LastName><ForeName>Marion C</ForeName><Initials>MC</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-5594-2319</Identifier><AffiliationInfo><Affiliation>University of Zurich, Department of Plant and Microbial Biology, Zollikerstrasse 107, 8008, Zürich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Molnár</LastName><ForeName>István</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Institute of Experimental Botany, Czech Academy of Sciences, Centre of the Region Haná for Biotechnological and Agricultural Research, Šlechtitelů 31, 779 00, Olomouc, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mascher</LastName><ForeName>Martin</ForeName><Initials>M</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-6373-6013</Identifier><AffiliationInfo><Affiliation>Leibniz Institute of Plant Genetics and Crop Plant Research, OT Gatersleben, Corrensstr. 3, D-06466, Stadt Seeland, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holušová</LastName><ForeName>Kateřina</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Institute of Experimental Botany, Czech Academy of Sciences, Centre of the Region Haná for Biotechnological and Agricultural Research, Šlechtitelů 31, 779 00, Olomouc, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Šimková</LastName><ForeName>Hana</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute of Experimental Botany, Czech Academy of Sciences, Centre of the Region Haná for Biotechnological and Agricultural Research, Šlechtitelů 31, 779 00, Olomouc, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kunz</LastName><ForeName>Lukas</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>University of Zurich, Department of Plant and Microbial Biology, Zollikerstrasse 107, 8008, Zürich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Jianping</ForeName><Initials>J</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-2488-5723</Identifier><AffiliationInfo><Affiliation>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Jianbo</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>University of Sydney, School of Life and Environmental Sciences, Plant Breeding Institute, 107 Cobbitty Road, Cobbitty, NSW, 2570, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bhatt</LastName><ForeName>Dhara</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sharma</LastName><ForeName>Raghvendra</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schudel</LastName><ForeName>Seraina</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>University of Zurich, Department of Plant and Microbial Biology, Zollikerstrasse 107, 8008, Zürich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Guotai</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>John Innes Centre, Norwich, NR4 7UH, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Steuernagel</LastName><ForeName>Burkhard</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>John Innes Centre, Norwich, NR4 7UH, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Periyannan</LastName><ForeName>Sambasivam</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wulff</LastName><ForeName>Brande</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>John Innes Centre, Norwich, NR4 7UH, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ayliffe</LastName><ForeName>Mick</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McIntosh</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>University of Sydney, School of Life and Environmental Sciences, Plant Breeding Institute, 107 Cobbitty Road, Cobbitty, NSW, 2570, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Keller</LastName><ForeName>Beat</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>University of Zurich, Department of Plant and Microbial Biology, Zollikerstrasse 107, 8008, Zürich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lagudah</LastName><ForeName>Evans</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Commonwealth Scientific & Industrial Research Organisation, Agriculture & Food, GPO Box 1700, Canberra, ACT, 2601, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Sydney, School of Life and Environmental Sciences, Plant Breeding Institute, 107 Cobbitty Road, Cobbitty, NSW, 2570, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Peng</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>University of Sydney, School of Life and Environmental Sciences, Plant Breeding Institute, 107 Cobbitty Road, Cobbitty, NSW, 2570, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>11</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>New Phytol</MedlineTA><NlmUniqueID>9882884</NlmUniqueID><ISSNLinking>0028-646X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">AvrPm effectors</Keyword><Keyword MajorTopicYN="N">Bgt</Keyword><Keyword MajorTopicYN="N">Blumeria graminis f. sp. tritici</Keyword><Keyword MajorTopicYN="N">EMS mutagenesis</Keyword><Keyword MajorTopicYN="N">NLR</Keyword><Keyword MajorTopicYN="N">Triticum aestivum</Keyword><Keyword MajorTopicYN="N">chromosome sequencing</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>11</Month><Day>11</Day><Hour>17</Hour><Minute>14</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>11</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>11</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33176001</ArticleId><ArticleId IdType="doi">10.1111/nph.17075</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Royaume-Uni</li><li>République tchèque</li><li>Suisse</li></country><region><li>Canton de Zurich</li><li>Nouvelle-Galles du Sud</li></region><settlement><li>Sydney</li><li>Zurich</li></settlement><orgName><li>Université de Sydney</li><li>Université de Zurich</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="Hewitt, Tim" sort="Hewitt, Tim" uniqKey="Hewitt T" first="Tim" last="Hewitt">Tim Hewitt</name></noRegion><name sortKey="Ayliffe, Mick" sort="Ayliffe, Mick" uniqKey="Ayliffe M" first="Mick" last="Ayliffe">Mick Ayliffe</name><name sortKey="Bhatt, Dhara" sort="Bhatt, Dhara" uniqKey="Bhatt D" first="Dhara" last="Bhatt">Dhara Bhatt</name><name sortKey="Hewitt, Tim" sort="Hewitt, Tim" uniqKey="Hewitt T" first="Tim" last="Hewitt">Tim Hewitt</name><name sortKey="Lagudah, Evans" sort="Lagudah, Evans" uniqKey="Lagudah E" first="Evans" last="Lagudah">Evans Lagudah</name><name sortKey="Lagudah, Evans" sort="Lagudah, Evans" uniqKey="Lagudah E" first="Evans" last="Lagudah">Evans Lagudah</name><name sortKey="Li, Jianbo" sort="Li, Jianbo" uniqKey="Li J" first="Jianbo" last="Li">Jianbo Li</name><name sortKey="Mcintosh, Robert" sort="Mcintosh, Robert" uniqKey="Mcintosh R" first="Robert" last="Mcintosh">Robert Mcintosh</name><name sortKey="Periyannan, Sambasivam" sort="Periyannan, Sambasivam" uniqKey="Periyannan S" first="Sambasivam" last="Periyannan">Sambasivam Periyannan</name><name sortKey="Sharma, Raghvendra" sort="Sharma, Raghvendra" uniqKey="Sharma R" first="Raghvendra" last="Sharma">Raghvendra Sharma</name><name sortKey="Zhang, Jianping" sort="Zhang, Jianping" uniqKey="Zhang J" first="Jianping" last="Zhang">Jianping Zhang</name><name sortKey="Zhang, Peng" sort="Zhang, Peng" uniqKey="Zhang P" first="Peng" last="Zhang">Peng Zhang</name></country><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Mueller, Marion C" sort="Mueller, Marion C" uniqKey="Mueller M" first="Marion C" last="Mueller">Marion C. Mueller</name></region><name sortKey="Keller, Beat" sort="Keller, Beat" uniqKey="Keller B" first="Beat" last="Keller">Beat Keller</name><name sortKey="Kunz, Lukas" sort="Kunz, Lukas" uniqKey="Kunz L" first="Lukas" last="Kunz">Lukas Kunz</name><name sortKey="Schudel, Seraina" sort="Schudel, Seraina" uniqKey="Schudel S" first="Seraina" last="Schudel">Seraina Schudel</name></country><country name="République tchèque"><noRegion><name sortKey="Molnar, Istvan" sort="Molnar, Istvan" uniqKey="Molnar I" first="István" last="Molnár">István Molnár</name></noRegion><name sortKey="Holusova, Kate Ina" sort="Holusova, Kate Ina" uniqKey="Holusova K" first="Kate Ina" last="Holušová">Kate Ina Holušová</name><name sortKey="Simkova, Hana" sort="Simkova, Hana" uniqKey="Simkova H" first="Hana" last="Šimková">Hana Šimková</name></country><country name="Allemagne"><noRegion><name sortKey="Mascher, Martin" sort="Mascher, Martin" uniqKey="Mascher M" first="Martin" last="Mascher">Martin Mascher</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Yu, Guotai" sort="Yu, Guotai" uniqKey="Yu G" first="Guotai" last="Yu">Guotai Yu</name></noRegion><name sortKey="Steuernagel, Burkhard" sort="Steuernagel, Burkhard" uniqKey="Steuernagel B" first="Burkhard" last="Steuernagel">Burkhard Steuernagel</name><name sortKey="Wulff, Brande" sort="Wulff, Brande" uniqKey="Wulff B" first="Brande" last="Wulff">Brande Wulff</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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